Indianapolis Colts vs. Buffalo Bills Matchup Preview (11/21/21): Betting Odds, Depth Charts, Live Stream (Watch Online)

Indianapolis Colts vs. Buffalo Bills Matchup Preview (11/21/21)

In week 11, the Indianapolis Colts travel to Buffalo to play an old division rival the Bills.  Indianapolis and Buffalo played in the old AFC East through the 2001 season.  The Colts are coming off a 23-17 victory over the Jaguars, pushing their record to 5-5.  Indianapolis has won five of their last seven games after starting the season 0-3.  The Bills who lead the AFC East with a 6-3 record annihilated the Jets in week 10, 45-17.  This was Buffalo’s sixth victory by more than 25 points since 2020; most in the NFL during that time.  

Indianapolis Colts vs. Buffalo Bills Betting Odds

The Bills enter the games a 7.5-point home favorite.  The Colts are 6-4 against the spread this season; 2-2 on the road.  Buffalo’s last 13 wins have all been by more than 10 points, which is the longest streak since the St. Louis Rams in 1998-99.  The Colts have not beaten a team with .500 or better record in 2021.  Buffalo has scored 30 or more points in six games this season.  Indianapolis has allowed 30 or more points three times this season to their opponents.

My Prediction: Bills 35-24, Bills cover and the game will go over the over/under of 50 points.  

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TV Schedule

Date: 21st, November 2021
Time: 1:00 PM ET
Location: Highmark Stadium – Orchard Park, NY
TV Coverage: CBS

Indianapolis Colts vs. Buffalo Bills Live Stream

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Indianapolis Colts Analysis

The Colts are averaging 363.4 yards of total offense per game.  Quarterback Carson Wentz threw for 180 yards in the win vs. Jacksonville in week 10.   In the victory, he did not throw a touchdown pass for the first time in seven games.  Over those seven games, Wentz tossed 14 touchdown passes.  In his first season with Indianapolis, he has thrown for 2,378 yards, 17 touchdowns, three interceptions with a 63.5 completion percentage.  After being sacked a league high 50 times last season, Wentz has been sacked 18 times this season.  Wentz’s health will be a huge factor as the season progresses.  When healthy he is one of the most dynamic quarterbacks in the NFL.

Michael Pittman Jr. caught seven passes for 71 yards in the win against Jacksonville, but his streak of three straight games with receiving touchdown came to an end.  The second-year receiver from USC is leading the Colts in receiving with 55 receptions for 729 yards and five touchdowns.  In 23 career games, he’s averaging 13 yards per reception.  

In the win vs. Jacksonville, Jonathan Taylor rushed for 116 yards and a touchdown, becoming the fourth player to score a touchdown and produce 100 yards from scrimmage in seven straight games during the Super Bowl era.   He’s currently tied with the injured Derrick Henry for the lead in rushing yards with 937.  The Colts #28 is averaging 93.7 yards per game and has scored nine rushing touchdowns in 2021.   Per PFF, Taylor has forced 37 missed tackles on runs this season.  The former Wisconsin Badger is the fourth player in Colts history with at least 2,000 yards rushing in their first two seasons.  Currently, Jonathan Taylor is +10000 to win the 2021 NFL MVP.  

The Indianapolis defense is allowing 363.4 yards per game; putting them in the top half of the league.  They’re second in the league, behind Buffalo in turnovers with 21 (10 interceptions and 11 fumble recoveries).  Linebacker Darius Leonard is tied for the team lead in interceptions with two.  On the season, Leonard has 44 solo tackles, three tackles for loss and two quarterback hits.  He left last Sunday’s game with an ankle injury but returned to the game.  The injury is something to watch out for as the week moves forward.  In his second season as a Colt, DeForest Buckner is leading the team with 4.5 sacks, he also has six tackles for loss and 11 quarterback hits.  

Indianapolis Colts Depth Chart

QB: Carson Wentz
RB1: Jonathan Taylor
RB2: Nyheim Hines
WR1: Parris Campbell
WR2: Zach Pascal
WR3: Michael Pittman Jr.
TE1: Jack Doyle

Buffalo Bills Analysis

The Bills offense is averaging 401.1 yards per game ranking them fifth in the NFL.  After a tough performance against the Jaguars last week, Josh Allen rebounded with a dominating performance over the beleaguered Jets defense.  Allen threw for 366 yards, two touchdowns with a 125.6 quarterback rating.  He has 12 300-yard passing games in his career; no other Buffalo quarterback had more than nine games in their first four seasons.  The Bills are 15-1 since 2019, when Josh Allen has at least one passing touchdown or one rushing touchdown in the first quarter.   On the season, the Wyoming product has accounted for 2,924 yards of total offense (2,602 passing and 322 rushing).  He’s also thrown 19 touchdowns and rushed for another three in 2021.  An incredible stat courtesy of, the Bills #17 has 59 passing touchdowns and no interceptions in the red zone in his career; including the playoffs, which is the most passing touchdowns without an interception since 2018.  With the victory over the Jets, Allen is listed at +200 to win the 2021 NFL MVP.  

Buffalo’s rushing attack is averaging 121.9 yards per game this season.  Devin Singletary is the Bills leading rusher with 398 yards; averaging five yards per carry.  In the game vs. the New York Jets, Buffalo became the first team to have four players with at least one rushing touchdown since New Orleans accomplished that feat in 2017.

Against the Jets in week 10, Stefon Diggs had eight receptions for 162 yards and a touchdown: averaging 20.3 yards per reception.  Diggs leads the team with 56 receptions for 750 yards: while scoring four touchdowns.  Cole Beasley is second on the team in receiving with 53 catches for 461 yards and a touchdown: averaging 8.7 yards per catch in 2021.  He also has at least one reception in each of his 39 games played with the Bills since joining the team in 2019.  Tight End Dawson Knox is leading the team in touchdown receptions this season with five; averaging 13.8 yards per catch this season.  

Buffalo has the number one ranked defense allowing 274.1 yards per game to their opponents.  The unit has two shutouts on the season and is allowing 15 points per game: ranking them first in the NFL.  The Bills defense has allowed six passing touchdowns this season and 190.2 passing yards per game, second in the NFL.  Finally, they lead the league in takeaways with 24 (15 interceptions and 9 fumble recoveries).  

Buffalo Bills Depth Chart

QB: Josh Allen
RB1: Zack Moss
RB2: Devin Singletary
WR1: Stefon Diggs
WR2: Emmanuel Sanders
WR3: Cole Beasley
TE1: Dawson Knox
TE2: Tommy Sweeney

Indianapolis Colts vs. Buffalo Bills Daily Fantasy Picks

Per, Jonathan Taylor has at least 18 fantasy points in seven straight games, it’s the longest streak by a Colts running back since the great Edgerrin James did so in 2005.  The second-round pick in the 2020 draft has at least one touchdown in seven straight games and has 1,240 yards from scrimmage which is leading the NFL. 

The Bills Stefon Diggs has scored at least 15 fantasy points 18 times since 2020, per  He’s averaging 6.2 receptions and 83.3 yards per game this campaign.  He has 42 touchdown receptions in 95 career games.

Week 11 Matchup Previews
  • Bills @ Rams
  • Saints @ Falcons
  • Browns @ Panthers
  • 49ers @ Bears
  • Steelers @ Bengals
  • Eagles @ Lions
  • Colts @ Texans
  • Patriots @ Dolphins
  • Ravens @ Jets
  • Jaguars @ Commanders
  • Giants @ Titans
  • Chiefs @ Cardinals
  • Raiders @ Chargers
  • Packers @ Vikings
  • Buccaneers @ Cowboys
  • Broncos @ Seahawks
Scott has been a sports fan since he received a New York Mets jacket as a toddler. He’s been playing fantasy baseball and football for over 20 years, dating back to Frank Thomas being one of his first fantasy baseball picks. As a professional, he has covered the NFL, MLB, NCAAF, and NCAAB and is looked to as the go-to guy for fantasy sports amongst family, friends, and co-workers.

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