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  5. San Francisco 49ers at Arizona Cardinals Matchup 11/16/25 49ers at Cardinals Matchup 11/16

San Francisco 49ers at Arizona Cardinals Matchup 11/16/25

12-5, 6th NFC West
at

SF 41 @ ARI 22

State Farm Stadium, Final

Updated: 11:25 pm GMT

3-14, 16th NFC West

SF 41 @ ARI 22

State Farm Stadium, Final

Updated:

Updated: 11:25 pm GMT

Odds Odds Comparison | Splits Bet Splits | Scoring | L5 Meet Last 5 Meetings | ARI 49ers L5 Last 5 | ARI Cardinals L5 Last 5

Updated: 11:25 pm GMT, 2/28

Matchup

Game Spread Over/Under Moneyline Charts
Teams Team Rating Defense Rating Offense Rating Open Closing Open Closing Open Closing Line Moves
San Francisco 49ers San Francisco 49ers 49ers
83
85
82
-1.5 (-108)
-3.5 (+100)
47.5 pts
48.5 pts
-125
-185
line-movement
Arizona Cardinals Arizona Cardinals Cardinals
75
74
76
+1.5 (-112)
+3.5 (-120)
+100
+156
47.5 pts
48.5 pts

Odds Comparison

Vegas Odds
San Francisco 49ers San Francisco 49ers 49ers
Arizona Cardinals Arizona Cardinals Cardinals
Moneyline -185 +156
Spread -3.5 +3.5
Totals 26 22.5
Win Probability 61% 39%
Over/Under
Over/Under 48.5
Over/Under History
Over/Under Home Away Grass Turf
San Francisco 49ers San Francisco 49ers 49ers
7-3-1 2-2-0 5-1-1 4-2-0 3-1-1
Arizona Cardinals Arizona Cardinals Cardinals
6-4-0 4-1-0 2-3-0 4-2-0 2-2-0
San Francisco 49ers San Francisco 49ers 49ers
Arizona Cardinals Arizona Cardinals Cardinals
Line Overall Home Away Overall Home Away
36 or less 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0
36.1 to 39 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0
39.1 to 43 1-0-1 0-0-0 1-0-1 1-0-0 1-0-0 0-0-0
43.1 to 46 2-2-0 1-1-0 1-1-0 3-3-0 2-1-0 1-2-0
46.1 and over 4-1-0 1-1-0 3-0-0 2-1-0 1-0-0 1-1-0
Against the Spread(ATS) History
ATS Home Away Grass Turf
San Francisco 49ers San Francisco 49ers 49ers
6-5-0 1-3-0 5-2-0 2-4-0 4-1-0
Arizona Cardinals Arizona Cardinals Cardinals
5-5-0 1-4-0 4-1-0 2-4-0 3-1-0
San Francisco 49ers San Francisco 49ers 49ers
Arizona Cardinals Arizona Cardinals Cardinals
Line Overall Home Away Overall Home Away
-10.1 or More 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0
-7 to -10 0-0-0 0-0-0 0-0-0 0-2-0 0-2-0 0-0-0
-3.1 to -6.9 1-1-0 0-1-0 1-0-0 1-0-0 0-0-0 1-0-0
-0.1 to -3 3-1-0 0-1-0 3-0-0 0-0-0 0-0-0 0-0-0
0 to 3 1-1-0 1-0-0 0-1-0 1-1-0 0-1-0 1-0-0
+3.1 to +6.9 0-2-0 0-1-0 0-1-0 2-1-0 1-1-0 1-0-0
+7 to +10 1-0-0 0-0-0 1-0-0 1-1-0 0-0-0 1-1-0
10.1 or more 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0 0-0-0

Bet Splits

San Francisco 49ers San Francisco 49ers 49ers
Record Win % Cover Spread % Avg Point Totals
Away 4-2 66.7% 66.7 22.8
Favorite 4-1 80% 60 22.8
After Loss 3-0 100% 30 8
Arizona Cardinals Arizona Cardinals Cardinals
Record Win % Cover Spread % Avg Point Totals
Home 1-3 25% 25 22.8
Underdog 1-5 16.7% 66.7 22.3
After Loss 1-4 20% 33.3 13.1

Scoring

Offense Scoring (Home)
Total 1st Quarter 2nd Quarter 3rd Quarter 4th Quarter
San Francisco 49ers San Francisco 49ers 49ers
20.8 0.8 6.5 4.5 9
Arizona Cardinals Arizona Cardinals Cardinals
22.8 7.5 6.8 4.2 4.2
Defense Scoring Allowed (Away)
Total 1st Quarter 2nd Quarter 3rd Quarter 4th Quarter
San Francisco 49ers San Francisco 49ers 49ers
24.2 5.6 9.4 1.2 8
Arizona Cardinals Arizona Cardinals Cardinals
22.8 2.8 8.3 5.2 6.5
Offense Scoring (Away)
Total 1st Quarter 2nd Quarter 3rd Quarter 4th Quarter
San Francisco 49ers San Francisco 49ers 49ers
22.8 5 8.3 3.3 5.7
Arizona Cardinals Arizona Cardinals Cardinals
22.2 2.6 8.2 7.6 3.8
Defense Scoring Allowed (Home)
Total 1st Quarter 2nd Quarter 3rd Quarter 4th Quarter
San Francisco 49ers San Francisco 49ers 49ers
23.2 3.5 7.5 6.5 5.8
Arizona Cardinals Arizona Cardinals Cardinals
23.5 3.2 4 4 12.2

Last 5 Meetings

Game
San Francisco 49ers San Francisco 49ers 49ers
Arizona Cardinals Arizona Cardinals Cardinals
Date Score Spread Over/Under Total Yds Rush Yds Pass Yds Rush TDs Pass TDs Total Yds Rush Yds Pass Yds Rush TDs Pass TDs
9/21/25 ARI 15 @ SF 16 SF -1 44.5 points 355 73 282 0 1 260 106 154 0 1
1/5/25 SF 24 @ ARI 47 ARI -5 43 points 0 0 0 0 0 0 0 0 0 0
10/6/24 ARI 24 @ SF 23 SF -7 49 points 384 153 231 0 1 358 169 189 1 1
12/17/23 SF 45 @ ARI 29 SF -12 48 points 406 144 262 1 4 436 234 202 2 1
10/1/23 ARI 16 @ SF 35 SF -14 44 points 395 124 271 4 1 362 105 257 0 2

San Francisco 49ers Last 5 Matchups

Game
San Francisco 49ers San Francisco 49ers 49ers
Opponent
Date Score Spread Over/Under Total Rush Yds Pass Yds Rush TDs Pass TDs Total Rush Yds Pass Yds Rush TDs Pass TDs
11/9/25 SF 26 vs LAR 42 LAR -5.5 49.5 points 393 74 319 1 3 401 126 275 2 4
11/2/25 SF 34 @ NYG 24 SF -2.5 47.5 points 380 159 221 2 2 296 117 179 1 2
10/26/25 SF 15 @ HOU 26 HOU -3.0 41 points 223 48 175 0 2 475 157 318 0 2
10/20/25 SF 20 vs ATL 10 ATL -1.0 46.5 points 324 174 150 2 0 292 62 230 0 1
10/12/25 SF 19 @ TB 30 TB -3.5 46.5 points 363 67 296 1 0 352 104 248 2 2

Arizona Cardinals Last 5 Matchups

Game
Arizona Cardinals Arizona Cardinals Cardinals
Opponent
Date Score Spread Over/Under Total Rush Yds Pass Yds Rush TDs Pass TDs Total Rush Yds Pass Yds Rush TDs Pass TDs
11/9/25 ARI 22 @ SEA 44 SEA -7.0 44.5 points 335 129 206 1 2 372 198 174 2 1
11/4/25 ARI 27 @ DAL 17 DAL -3.5 53.5 points 340 119 221 1 2 333 123 210 0 1
10/19/25 ARI 23 vs GB 27 GB -7.0 44.5 points 330 94 236 0 2 262 94 168 2 1
10/12/25 ARI 27 @ IND 31 IND -9.0 46 points 400 88 312 1 2 355 150 205 2 2
10/5/25 ARI 21 vs TEN 22 ARI -7.5 41.5 points 360 168 192 3 0 327 78 249 1 0